IUGR prevents IGF-1 upregulation in juvenile male mice by perturbing postnatal IGF-1 chromatin remodeling
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چکیده
منابع مشابه
Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines.
The insulin-like growth factors (IGFs) are a family of mitogenic proteins involved in the regulation of cell growth and differentiation. The presence and role of the IGF system in oral mucosal epithelium is not clear but could influence our understanding of the pathogenesis of oral cancer. We characterised the expression and function of IGF-1, IGF-2 and IGF receptor in human oral squamous carci...
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Insulin-like Growth Factor-1 (IGF-1) is a naturally occurring peptide with roles in both the endocrine (hormonal) systems, along with autocrine/paracrine activity at a cellular level. IGF-1 can be measured relatively easily in blood with appropriate techniques. The concentration of IGF-1 circulating in the blood plasma of weaned (juvenile) piglets has significant genetic correlations with sever...
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IGF-1 and IGF-2 are potent mitogens acting through the IGF-1 receptor (IGF-1R). The importance of the IGF system in neoplasia has been demonstrated in several models, and IGF-1 signaling has become a target for drug development. The drug candidate BI 836845 is a fully human IgG1 ligand-neutralizing antibody that cross-reacts with IGF-1 and IGF-2. It has been shown to reduce both IGF-1R phosphor...
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To investigate whether insulin-like growth factor (IGF)-1 and IGF-binding protein-3 (IGFBP-3) are prospectively associated with exocrine pancreatic cancer, we conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 29,133 male Finnish smokers, aged 50-69 years. To avoid the potential influence of subclinical cancer on IGF-1 and IGFBP-3,...
متن کاملCorrection: IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice
[This corrects the article DOI: 10.1371/journal.pone.0170083.].
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2015
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2015.70